在你問某人發生了什麼事或遇到了什麼問題的時候就可以說 "what's up?"。
What's up? I came to your house to party and everybody is sitting around looking sad.
What's up with Lauren? She's been acting in a very strange way.
在美式英語裏，"what』s up?" 是一個常見的打招呼用語，意思是"你好嗎？"
What's up, Frank? I haven't seen you in ages.